Infection Prevention and Control

Introduction: Infections with antimicrobial resistance (AMR) germs are a strong concern of present medical practice, imposing a stringent need for efforts to identify alternative treatment approaches. Chicken Immunologically Active Proteins (CIAP) including Immunoglobulin (Ig)-Y represent powerful tools obtained from the eggs of chickens immunized with antigens of the hospital-isolated AMR germs (1-3). This study presents the use of CIAP in AMR infections of bones, joints and soft tissue in Romanian patients. 

Patients group: We have performed a study on 8 patients (6 male and 2 female) aged 43 to 72 years with AMR infections of bones, joints and soft tissue of the lower limbs and with diverse superposed debilitating pathologies (uncontrolled diabetes mellitus, high blood pressure, atheromatous arteriopathy) that were treated orally and topically with CIAP. Patients were subjected to thorough medical investigations including haemoleucogram, inflammatory markers, glycemia, liver and kidney function tests, vascular imaging, lower limb radiographs, microbiological culture from wounds and pus collections. In diabetic patients, glycemic control was acquired by insulin or oral antidiabetic drugs administration and in one patient the blood flow to the affected lower limbs was restored by axillary-bi-iliac by-pass. Orthopedic surgery was performed in order to correct bone and joints pathology.

Results: The evolution was favourable after orthopedic surgery in all patients treated orally and topically with CIAP in the absence of any simultaneous antibiotic treatment, thus salvaging the affected inferior limbs. CIAP treatment led to buildup of

bone, remodelling of soft tissue and recovery of independent ambulatory capabilities. The obtained results are very suggestive of the immunomodulatory actions and treatment potency of CIAP products in infections with AMR germs in humans