15^th World Congress on Infection Prevention and Control October 21-22, 2019 ZURICH | SWITZERLAND Venue: Movenpick Hotel Zürich Airport

Biography:

Abstract:

Biography:

Abstract:

Biography:

Jaroslav A Hubacek has his expertise in research focused on the genetic of non-communicable diseases and their risk factors in humans and in animal models. He is interested on gene-gene and gene-environment interactions, roles of both macro- and micro- nutrients in human wellbeing (nutrigenetic), pharmacogenetic and actigenetic.

Abstract:

Statement of the Problem: Genome-wide association studies have resulted in the identification of the FTO gene as an important genetic determinant of diabetes mellitus. The aim of this study was to confirm the role of this gene in the development of DM in the Czech-Slavonic population and to analyse whether this gene is associated with common DM complications.  Methodology &

Theoretical Orientation: Two groups of patients (814 with T1DM and 848 with T2DM) and a group of healthy controls (2,339 individuals) – both of Czech origin – were genotyped for the FTO rs17817449 SNP. ANOVA and logistic regression were used for the statistical evaluations

Findings: The frequency of the GG genotype was significantly higher in T2DM (25.4% vs. 16.7%, P<0.0005) but not in T1DM patients (19.3% vs. 16.7%, P=0.20) than in controls. The increased risk of development of diabetic nephropathy was observed both for T1DM patients (GG vs. TT homozygotes, P<0.01) and T2DM patients (G carriers vs. TT homozygotes, P<0.05). FTO genotype predicted the development of diabetic neuropathy (GG vs. TT comparison; P<0.01) in the T2DM patients only. No association between FTO genotype and development of retinopathy was detected. All presented values are after adjustment for age, sex, BMI and duration of diabetes. Conclusion & Significance: We confirm the association between the FTO rs17817449 SNP and susceptibility to T2DM in the Czech-Slavonic population. The same variant is associated with a spectrum of chronic complications in both types of diabetes.

Biography:

Olufunmilayo Olukemi Akapo has completed her graduation at Rivers State University of Science Technology, Nigeria. She obtained her MSc degree in Biochemistry from University of Zululand. She is presently a PhD candidate at the University of Zululand South Africa, under the supervision of Prof Khajamohiddin Syed; a researcher who is well known with P450s enzyme researches. Her on-going research is focused on the role of P450s in relation to cryptococcal disease, a disease which majorly affects immunocompromised patients. She has been able to present her different research results in conferences and symposiums.

Abstract:

Tremellomycetes, a fungal class in the subphylum Agaricomycotina, contain well-known opportunistic and emerging human pathogens. The azole drug fluconazole, used in the treatment of diseases caused by some species of Tremellomycetes, inhibits cytochrome P450 monooxygenase CYP51, an enzyme that converts lanosterol into an essential component of the fungal cell membrane ergosterol. Studies indicate that mutations and over-expression of CYP51 in species of Tremellomycetes are one of the reasons for fluconazole resistance. Moreover, the novel drug, VT-1129, that is in the pipeline is reported to exert its effect by binding and inhibiting CYP51. Despite the importance of P450s, the P450 repertoire in species of Tremellomycetes has not been reported to date. This study intends to address this research gap. Comprehensive genome-wide P450 analysis revealed the presence of 203 P450s (excluding 16 pseudo- P450s) in 23 species of Tremellomycetes that can be grouped into 38 P450 families and 72 P450 subfamilies. Twenty-three P450 families are new and three P450 families (CYP5139, CYP51 and CYP61) were conserved across 23 species of Tremellomycetes. Pathogenic cryptococcal species have 50% fewer P450 genes than non-pathogenic species. The results of this study will serve as reference for future annotation and characterization of P450s in species of Tremellomycetes.

Biography:

Christian Kwasi Agyeman is the president of Taabea group, It’s consist of Taabea company limited, producers of an effective organic medicine  for the treatment of malaria in Ghana,that has won several awards both internationally and locally,we have Taabea television channel,Nyame ne Hene cold store, distributors of frozen meat,chris rice company limited ,Taabea television sets,Chrisagye global, into constructions and kiss me hair food pomade for hair .Dr Christian Kwasi Agyeman is from Brong Ahafo Region of Ghana holding a  honoring doctorate degree from Ternopil  medical university of Ukraine and He won the best malaria herbal mixture producer  of the year 2018 in Ghana and Africa, A researcher of malaria infections and treatment for ten(10) good years.

Abstract:

Malaria is a preventive and curable diseases in Africa.

Malaria is a parasitic disease caused by an anopheles mosquito thus, the female mosquitoes. This disease is caused by a plasmodium parasite, transmitted by the bite of infected mosquitoes. The severity of malaria depends on the species of plasmodium.

The parasites in mosquitos that spread malaria belong to the Plasmodium genus. Over 100 types of Plasmodium parasite can infect a variety of species. Different types replicates the rates, changing how quickly the symptoms escalate, either severe or uncomplicated.

CAUSES

Mosquito species have different breeding habits, but most want to lay their eggs near water – usually in vegetation or in stagnant water because of the humid temperatures. Female mosquitoes (Anopheles Mosquitoes) which causes malaria, can produce 100-300 eggs at one time, and the eggs can hatch into mosquito larvae within 48 hours.

HOW MALARIA SPREADS

Malaria happens when a bite from the female Anopheles mosquito infects the body with Plasmodium. Only the Anopheles mosquito can transmit malaria. This transmission is done mostly during the evening but not day because of the exposure to sunlight which can kill by dehydrating. Anopheles mosquitoes enter the house between 5 p.m. and 9.30 p.m. and again in early hours of morning. They start biting by late evening and the peak of biting activity is at midnight and early hours of morning.

SYMPTOMS

Symptoms of malaria can be grouped into two (2) categories, thus Uncomplicated and severe malaria.

1.  Uncomplicated symptom of Malaria

This symptoms progress with Cold, a sensation of cold with shivering, fever, headaches, and vomiting, seizures sometimes occur in younger people with the disease, sweats, followed by a return to normal temperature, with tiredness  and mostly last for 6-10hrs.

2. Sever symptoms of Malaria

     Severe malaria, clinical or laboratory evidence shows signs of vital organ dysfunction with      fever and chills, impaired consciousness ,prostration, or adopting a prone position, multiple convulsions, deep breathing and respiratory distress, abnormal bleeding and signs of anemia clinical jaundice.

PREVENTIVE MEAUSRES

1 – Distilling of shocked drainage system

2 – Clearing of Bushes (Unwanted Vegetation) which can inhabit mosquitoes

3 – Use of Mosquitoes repellents

CURING MALARIA

The Best and still existing HERBAL WAY to cure malaria is TAABEA HERBAL MIXTURE.

This a traditional preventive and curing system to get rid of malaria in your system. This product contains NATURAL and well grown HERBAL PLANTS that seek to boot your IMMUNE system up and enrich your blood cells to fight any parasite with your blood streams.

Biography:

Colombo D. Veronica  currently working in Treviglio-Caravaggio Hospital, Italy. Her main reach is on Pediatric Diabetes.

Abstract:

Objective

Diabetes is a chronic disease resulted of an absent or low product of Insulin Resistance or Tolerance with  a  large  diffusion  in  Italy 3.27  million  (5,4  of  population  by ISTAT),   we  note  a  prospective increase in a future for a major risk to have conditions due to this event. Whereas of Diabetes type II, Diabetes type 1 (DMT1), infant or mellitus is about 10% and is not prevent according scientific study with  auxological  screening  and  with  nutrition  schedule;  but  the  early  diagnosis  is  lifesaver  in  5 thousand cases every year.

Methods

The children’s accesses affected by Diabetes in our Emergency and Pediatric Department of Treviglio Hospital in the last10 years, since 1 January 2009 to 31 December 2018 is of 180 reports, 125 total patients. Of which 55 in follow-up and 4 transferred in the HUB center by competence, according to clinical conditions. 125 patients were share in two group by sex: 104 males e 21 females. While 180 reports were divided in two age-groups: pre-scholar 23, scholar and adolescent 157. Differential 125 patients: 123 with childhood Diabetes (with Italian code 775.1 and 250.1). MOBY cases 2 and 57 patients affected by comorbidity.

Results

From date of case-history, we need now analysis 3 groups with outset of diabetes during 2 years of life and of which 19.2%, with comorbidity 21.6%. Cases of Insulin-dipendent Diabetes after 2 years of life are 77,7% and con comorbidity in 24%. With comorbidity outset in the 39.2% and during follow-up in 42.4%. From report 21% of patients have the major part “Celiac Disease” and 6,4% other  infections  (HP  ed  enteritis).  We  note  28%  with  other  Metabolic-Endocrinological  Diseases (acute and chronic).

Conclusions

Reports untill 31 December 2018, we allow now to do a distinction: the first-period since 2009-2011 with early diagnosis in 20.6% and discovered in later age, respect the second-period since 2012-2014 con diagnosis more early with 38.4%. At the end, the early neonatal and mellitus DMT1 of last period, with predictive index in the 55.5% with a better stature-ponderal development, neurological-behavior and nutritional-compliance.

Biography:

Mitra Kazemi Jahromi is an Assistant Professor in the department of Endocrinology at Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Her Education was in General Practice at Shiraz University of Medical Sciences, Shiraz, Iran, in the Year of 2002 and Specialty of Internal Medicine at Tehran University of Medical Sciences, Tehran, Iran in 2011. She also did sub specialty of Endocrinology and Metabolism at Shahid Beheshti University of Medical Sciences, Research institute for endocrine sciences, Tehran, Iran in the year 2018. She published 8 papers about internal medicine and now working in Clinical Research Center and Endocrine Research Center of Hormozgan University of Medical Sciences with more focus on diabetic patients.

Abstract:

Introduction: Diabetic nephropathy is a major cause of ESRD. Research has demonstrated that blood glucose control delays microalbuminuria, but there is controversy on its effect on GFR reduction. This study examines the relationship between HbA1C and GFR in T2DM patients.

Methods: The relationships between two levels of HbA1C (≤8% and >8%) and two levels of GFR (≤60% and >60%) were separately examined in 802 T2DM patients. GFR was calculated using the MDRD and EPI. Considering the possible role of anemia in HbA1C interpretation, both the male and female patients were divided into groups with (men: 7<Hb<9, 9<Hb<13; women: 7<Hb<9, 9<Hb<12) and without (men: Hb≥13; women: Hb≥12) anemia. The relationship between HbA1C and GFR was evaluated overall and also separately by HbA1C and GFR (<60 and ≥60).

Results: A total of 74.5% of those with HbA1C≤8% and 71% of those with HbA1C>8% were female. GFR was measured using both EPI and MDRD and correlated significantly with HbA1C>8% (P=0.019, P=0.006). No significant relationship existed between GFR and HbA1C in the classification of GFR (≤60 and >60). A significant inverse relationship existed in the classification based on anemia level between GFR<60 and HbA1C>8% in women. This relationship was observed in those without anemia (HbA1C>12) using both EPI and MDRD (P=0.007, P=0.004). No significant relationship existed for the other hemoglobin levels and in the cases with HbA1C≤8%. No significant relationship existed between different GFRs and HbA1C in men.

Conclusion: In T2DM patients without anemia (Hb>12), a significant inverse relationship exists between HbA1C>8% and GFR≤60 (with both MDRD and EPI), i.e. GFR dropped significantly as HbA1C increased. This relationship was significant only in women, which constituted the majority of the study population. No significant relationship was observed at Hb<12, which could confirm the role of anemia as a confounding variable in the interpretation of HbA1C.

Biography:

Sumei Wang has completed her graduation at Sun-Yet Sun University and University of Texas MD Anderson Cancer Center. She has been studying oncology for more than 10 years and now is working on how traditional Chinese medicine treats human cancer and epigenetic alterations in cancers. She has published more than 30 papers in reputed journals and has been serving as reviewers for many SCI journals including Oncogene, Cancer Biology & Medicine, and Cancer Cell International and etc. Her area of research interest includes epigenetic modulations in human cancer and TCM treating human cancer.       

Abstract:

Our previous clinical study has shown that Chinese herbal medicine (CHM) Fuzheng Kang-Ai (FZKA for short) decoction is effective in treating advanced lung cancer patients through prolonging the drug resistance to gefitinib. Our basic study found that FZKA decoction could enhance the inhibition effect of gefitinib in lung cancer by inactivating PI3K/Akt pathway. Moreover, our recent work showed that FZKA induced lung cancer cell apoptosis via STAT3/Bcl-2/Caspase-3 Pathway. Thus in this study, we aim to elucidate how FZKA enhances the effect of gefitinib in lung cancer from the perspective of cell apoptosis. Firstly, our results showed that FZKA enhanced the inhibition effect of gefitinib in lung cancer both in vitro and in vivo. Secondly, cell apoptosis was enhanced when treated lung cancer cells with both FZKA and gefitinib, especially in a mitochondrial way. And Bcl-2 family was involved in this process. Interestingly, STAT3 plays a critical role on mediating the above process. Last but not the least, the enhanced effect of cell apoptosis induction of gefitinib by FZKA was validated in animal model. All in all, our findings conclude that Fuzheng Kang-Ai decoction enhances the effect of gefitinib-induced cell apoptosis in lung cancer through mitochondrial pathway. Our study provides a novel molecular mechanism by which FZKA prolongs the drug resistance to gefitinib in treating lung cancer patients.

Biography:

Basma Faiz Alharbi has completed her Bachelor of Nursing from Faculty of Nursing, King Abdul-Aziz University, Jeddah , Saudi Arabia and Certification Board of the American Institute for Healthcare Quality of Certified Professional in Infection Control. She is a Staff nurse in isolation unit at Prince Mohammed bin Abdulaziz Hospital, National Guard’s Health Affairs in Al Madinah Al Munawwarah, Saudi Arabia.

Abstract:

Essential health services are critically delivered by nurses and are the core of the strength of the healthcare system. Nurses are the first respondents to complex humanitarian crises, protectors and advocates for community health. Communication is a significant component of sound service provision. The communication quality between patients and nurses has a considerable influence on the outcome of the patient. Increased effective nurse communication can reduce medical errors and make a positive outcome in the patient's health. This study explores how effective communication can help control infection and increase patient outcomes, it also explains the methods that can be used for effective communication and their results if effectively used.